V6I (p.Val6Ile) variant of CYP2C19 (Cytochrome P450 2C19)
V6I (p.Val6Ile) in CYP2C19 (Cytochrome P450 2C19) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.19 / 1. The record also includes population frequency data, experimental measurements, published literature, and structural context.
V6I (p.Val6Ile) variant details
- p.Val6Ile
- gnomAD 10-94762721-G-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.192
- REVEL 0.03
- MetaLR 0.14
- MetaSVM -0.99
- CADD 0.96
- PolyPhen-2 0.07
- SIFT 0.63
- Most common in the Non-Finnish European population (allele frequency 3.4e-06)
- Structural context available
- CYP2C19 VAMP-seq nonsynonymous scores: score 1.06
- Literature evidence available