V64M (p.Val64Met) variant of CYP2C19 (Cytochrome P450 2C19)
V64M (p.Val64Met) in CYP2C19 (Cytochrome P450 2C19) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.56 / 1. The record also includes population frequency data, experimental measurements, and structural context.
V64M (p.Val64Met) variant details
- p.Val64Met
- ESP rs150045105
- ExAC rs150045105
- TOPMed rs150045105
- gnomAD rs150045105
- Missense
- Variant Prioritization Score for Impact Estimate 0.557
- REVEL 0.56
- MetaLR 0.52
- MetaSVM 0.04
- CADD 24.60
- PolyPhen-2 0.96
- SIFT 0.03
- Most common in the African/African-American population (allele frequency 2.8e-05)
- Structural context available
- CYP2C19 VAMP-seq nonsynonymous scores: score 0.274