V5M (p.Val5Met) variant of CYP2C19 (Cytochrome P450 2C19)
V5M (p.Val5Met) in CYP2C19 (Cytochrome P450 2C19) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.30 / 1. The record also includes population frequency data, experimental measurements, and structural context.
V5M (p.Val5Met) variant details
- p.Val5Met
- gnomAD rs1848187392
- Missense
- Variant Prioritization Score for Impact Estimate 0.298
- REVEL 0.18
- MetaLR 0.24
- MetaSVM -0.83
- CADD 9.24
- SIFT 0.07
- Most common in the Ashkenazi Jewish population (allele frequency 5.1e-05)
- Structural context available
- CYP2C19 VAMP-seq nonsynonymous scores: score 1.16