T66T (p.Thr66Thr) variant of CYP2C19 (Cytochrome P450 2C19)
T66T (p.Thr66Thr) in CYP2C19 (Cytochrome P450 2C19) is a synonymous change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.36 / 1. The record also includes population frequency data, experimental measurements, published literature, and structural context.
T66T (p.Thr66Thr) variant details
- p.Thr66Thr
- rs1209366478
- gnomAD 10-94775087-T-A
- Synonymous
- Variant Prioritization Score for Impact Estimate 0.356
- CADD 6.35
- PolyPhen-2 0.00
- SIFT 0.24
- Most common in the Non-Finnish European population (allele frequency 3.4e-06)
- Structural context available
- CYP2C19 VAMP-seq nonsynonymous scores: score 0.295
- Literature evidence available