T66S (p.Thr66Ser) variant of CYP2C19 (Cytochrome P450 2C19)
T66S (p.Thr66Ser) in CYP2C19 (Cytochrome P450 2C19) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.50 / 1. The record also includes population frequency data, experimental measurements, and structural context.
T66S (p.Thr66Ser) variant details
- p.Thr66Ser
- ExAC rs763322365
- gnomAD rs763322365
- Missense
- Variant Prioritization Score for Impact Estimate 0.502
- REVEL 0.50
- MetaLR 0.27
- MetaSVM -0.32
- CADD 23.30
- PolyPhen-2 0.77
- SIFT 0.26
- Most common in the Non-Finnish European population (allele frequency 9.9e-07)
- Structural context available
- CYP2C19 VAMP-seq nonsynonymous scores: score 0.295