T66I (p.Thr66Ile) variant of CYP2C19 (Cytochrome P450 2C19)
T66I (p.Thr66Ile) in CYP2C19 (Cytochrome P450 2C19) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.65 / 1. The record also includes population frequency data, experimental measurements, and structural context.
T66I (p.Thr66Ile) variant details
- p.Thr66Ile
- ExAC rs763322365
- gnomAD rs763322365
- Missense
- Variant Prioritization Score for Impact Estimate 0.648
- REVEL 0.67
- MetaLR 0.62
- MetaSVM 0.55
- CADD 23.90
- PolyPhen-2 0.97
- SIFT 0.08
- Most common in the 1KG:GIH population (allele frequency 0.0053)
- Structural context available
- CYP2C19 VAMP-seq nonsynonymous scores: score 0.295