T66A (p.Thr66Ala) variant of CYP2C19 (Cytochrome P450 2C19)
T66A (p.Thr66Ala) in CYP2C19 (Cytochrome P450 2C19) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.48 / 1. The record also includes population frequency data, experimental measurements, published literature, and structural context.
T66A (p.Thr66Ala) variant details
- p.Thr66Ala
- gnomAD 10-94775085-A-G
- Missense
- Variant Prioritization Score for Impact Estimate 0.476
- REVEL 0.46
- MetaLR 0.42
- MetaSVM 0.15
- CADD 22.60
- PolyPhen-2 0.41
- SIFT 0.42
- Most common in the Non-Finnish European population (allele frequency 1.6e-05)
- Structural context available
- CYP2C19 VAMP-seq nonsynonymous scores: score 0.295
- Literature evidence available