T55S (p.Thr55Ser) variant of CYP2C19 (Cytochrome P450 2C19)
T55S (p.Thr55Ser) in CYP2C19 (Cytochrome P450 2C19) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.23 / 1. The record also includes population frequency data, experimental measurements, and structural context.
T55S (p.Thr55Ser) variant details
- p.Thr55Ser
- 1000Genomes rs572853437
- ExAC rs572853437
- TOPMed rs572853437
- gnomAD rs572853437
- Missense
- Variant Prioritization Score for Impact Estimate 0.226
- REVEL 0.10
- MetaLR 0.12
- MetaSVM -0.93
- CADD 0.00
- PolyPhen-2 0.00
- SIFT 1.00
- Most common in the Non-Finnish European population (allele frequency 4.5e-06)
- Structural context available
- CYP2C19 VAMP-seq nonsynonymous scores: score 0.0277