T55N (p.Thr55Asn) variant of CYP2C19 (Cytochrome P450 2C19)
T55N (p.Thr55Asn) in CYP2C19 (Cytochrome P450 2C19) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.22 / 1. The record also includes population frequency data, experimental measurements, and structural context.
T55N (p.Thr55Asn) variant details
- p.Thr55Asn
- 1000Genomes rs572853437
- ExAC rs572853437
- TOPMed rs572853437
- gnomAD rs572853437
- Missense
- Variant Prioritization Score for Impact Estimate 0.217
- REVEL 0.08
- MetaLR 0.21
- MetaSVM -0.95
- CADD 0.05
- PolyPhen-2 0.01
- SIFT 0.28
- Most common in the Non-Finnish European population (allele frequency 1.6e-05)
- Structural context available
- CYP2C19 VAMP-seq nonsynonymous scores: score 0.0277