T55I (p.Thr55Ile) variant of CYP2C19 (Cytochrome P450 2C19)
T55I (p.Thr55Ile) in CYP2C19 (Cytochrome P450 2C19) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.22 / 1. The record also includes population frequency data, experimental measurements, published literature, and structural context.
T55I (p.Thr55Ile) variant details
- p.Thr55Ile
- gnomAD 10-94762869-C-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.224
- REVEL 0.08
- MetaLR 0.19
- MetaSVM -0.95
- CADD 1.83
- PolyPhen-2 0.02
- SIFT 0.16
- Most common in the Non-Finnish European population (allele frequency 9.9e-07)
- Structural context available
- CYP2C19 VAMP-seq nonsynonymous scores: score 0.0277
- Literature evidence available