S23R (p.Ser23Arg) variant of CYP2C19 (Cytochrome P450 2C19)
S23R (p.Ser23Arg) in CYP2C19 (Cytochrome P450 2C19) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as likely benign in the context of not specified. The available variant effect predictions contribute to a CATVariant prioritization score of 0.11 / 1. The record also includes population frequency data, experimental measurements, and structural context.
S23R (p.Ser23Arg) variant details
- p.Ser23Arg
- TOPMed rs1321377551
- gnomAD rs1321377551
- Likely benign
- not specified
- Missense
- Variant Prioritization Score for Impact Estimate 0.105
- REVEL 0.08
- MetaLR 0.10
- MetaSVM -1.00
- CADD 0.01
- PolyPhen-2 0.02
- SIFT 0.91
- ClinVar: Likely benign (not specified)
- EBI: Likely benign
- UniProt: Likely benign
- Most common in the Non-Finnish European population (allele frequency 4.5e-06)
- Structural context available
- CYP2C19 VAMP-seq nonsynonymous scores: score 0.96