R26T (p.Arg26Thr) variant of CYP2C19 (Cytochrome P450 2C19)
R26T (p.Arg26Thr) in CYP2C19 (Cytochrome P450 2C19) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.26 / 1. The record also includes population frequency data, experimental measurements, and structural context.
R26T (p.Arg26Thr) variant details
- p.Arg26Thr
- ExAC rs776992052
- gnomAD rs776992052
- Missense
- Variant Prioritization Score for Impact Estimate 0.265
- REVEL 0.08
- MetaLR 0.21
- MetaSVM -0.84
- CADD 15.40
- PolyPhen-2 0.53
- SIFT 0.12
- Most common in the HGDP:BIAKA population (allele frequency 0.93)
- Structural context available
- CYP2C19 VAMP-seq synonymous scores: score 0.926