R26K (p.Arg26Lys) variant of CYP2C19 (Cytochrome P450 2C19)
R26K (p.Arg26Lys) in CYP2C19 (Cytochrome P450 2C19) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.20 / 1. The record also includes population frequency data, experimental measurements, and structural context.
R26K (p.Arg26Lys) variant details
- p.Arg26Lys
- NCI-TCGA Cosmic COSV6490
- cosmic curated COSV64906
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.202
- REVEL 0.05
- MetaLR 0.13
- MetaSVM -0.99
- CADD 0.40
- PolyPhen-2 0.01
- SIFT 0.84
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the HGDP:MBUTI population (allele frequency 0.083)
- Structural context available
- CYP2C19 VAMP-seq synonymous scores: score 0.926