R21T (p.Arg21Thr) variant of CYP2C19 (Cytochrome P450 2C19)
R21T (p.Arg21Thr) in CYP2C19 (Cytochrome P450 2C19) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.12 / 1. The record also includes population frequency data, experimental measurements, and structural context.
R21T (p.Arg21Thr) variant details
- p.Arg21Thr
- ExAC rs772744604
- gnomAD rs772744604
- Missense
- Variant Prioritization Score for Impact Estimate 0.121
- REVEL 0.09
- MetaLR 0.22
- MetaSVM -0.86
- CADD 3.66
- PolyPhen-2 0.14
- SIFT 0.06
- Most common in the REMAINING population (allele frequency 1.7e-05)
- Structural context available
- CYP2C19 VAMP-seq nonsynonymous scores: score 0.888