R21I (p.Arg21Ile) variant of CYP2C19 (Cytochrome P450 2C19)
R21I (p.Arg21Ile) in CYP2C19 (Cytochrome P450 2C19) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.15 / 1. The record also includes population frequency data, experimental measurements, and structural context.
R21I (p.Arg21Ile) variant details
- p.Arg21Ile
- ExAC rs772744604
- gnomAD rs772744604
- Missense
- Variant Prioritization Score for Impact Estimate 0.151
- REVEL 0.12
- MetaLR 0.23
- MetaSVM -0.83
- CADD 10.00
- PolyPhen-2 0.08
- SIFT 0.04
- Most common in the Non-Finnish European population (allele frequency 2.3e-05)
- Structural context available
- CYP2C19 VAMP-seq nonsynonymous scores: score 0.888