Q22R (p.Gln22Arg) variant of CYP2C19 (Cytochrome P450 2C19)
Q22R (p.Gln22Arg) in CYP2C19 (Cytochrome P450 2C19) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.22 / 1. The record also includes population frequency data, experimental measurements, and structural context.
Q22R (p.Gln22Arg) variant details
- p.Gln22Arg
- ESP rs144928727
- ExAC rs144928727
- gnomAD rs144928727
- Missense
- Variant Prioritization Score for Impact Estimate 0.216
- REVEL 0.05
- MetaLR 0.17
- MetaSVM -0.97
- CADD 13.30
- PolyPhen-2 0.16
- SIFT 0.15
- Most common in the East Asian population (allele frequency 2.8e-05)
- Structural context available
- CYP2C19 VAMP-seq nonsynonymous scores: score 1.07