Q22E (p.Gln22Glu) variant of CYP2C19 (Cytochrome P450 2C19)
Q22E (p.Gln22Glu) in CYP2C19 (Cytochrome P450 2C19) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.27 / 1. The record also includes population frequency data, experimental measurements, and structural context.
Q22E (p.Gln22Glu) variant details
- p.Gln22Glu
- gnomAD rs1848189072
- Missense
- Variant Prioritization Score for Impact Estimate 0.267
- REVEL 0.09
- MetaLR 0.25
- MetaSVM -0.83
- CADD 14.30
- PolyPhen-2 0.23
- SIFT 0.04
- Most common in the Non-Finnish European population (allele frequency 1.6e-05)
- Structural context available
- CYP2C19 VAMP-seq nonsynonymous scores: score 1.07