P63T (p.Pro63Thr) variant of CYP2C19 (Cytochrome P450 2C19)
P63T (p.Pro63Thr) in CYP2C19 (Cytochrome P450 2C19) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.35 / 1. The record also includes population frequency data, experimental measurements, and structural context.
P63T (p.Pro63Thr) variant details
- p.Pro63Thr
- gnomAD rs1848387986
- Missense
- Variant Prioritization Score for Impact Estimate 0.347
- REVEL 0.22
- MetaLR 0.09
- MetaSVM -0.88
- CADD 23.20
- PolyPhen-2 0.94
- SIFT 0.00
- Most common in the African/African-American population (allele frequency 2.8e-05)
- Structural context available
- CYP2C19 VAMP-seq nonsynonymous scores: score -0.0408