P63L (p.Pro63Leu) variant of CYP2C19 (Cytochrome P450 2C19)
P63L (p.Pro63Leu) in CYP2C19 (Cytochrome P450 2C19) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.40 / 1. The record also includes population frequency data, experimental measurements, and structural context.
P63L (p.Pro63Leu) variant details
- p.Pro63Leu
- Ensembl rs868063722
- Missense
- Variant Prioritization Score for Impact Estimate 0.395
- REVEL 0.30
- MetaLR 0.16
- MetaSVM -0.64
- CADD 23.90
- PolyPhen-2 0.76
- SIFT 0.01
- Most common in the HGDP:BIAKA population (allele frequency 0.93)
- Structural context available
- CYP2C19 VAMP-seq nonsynonymous scores: score -0.0408