P3S (p.Pro3Ser) variant of CYP2C19 (Cytochrome P450 2C19)
P3S (p.Pro3Ser) in CYP2C19 (Cytochrome P450 2C19) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as drug response in the context of Voriconazole response; Citalopram response; Sertraline response. The available variant effect predictions contribute to a CATVariant prioritization score of 0.15 / 1. The record also includes population frequency data, experimental measurements, and structural context.
P3S (p.Pro3Ser) variant details
- p.Pro3Ser
- rs367543002
- cosmic curated COSV64907
- ClinVar RCV000782428
- 1000Genomes rs367543002
- drug response
- Voriconazole response; Citalopram response; Sertraline response
- Missense
- Variant Prioritization Score for Impact Estimate 0.145
- REVEL 0.15
- MetaLR 0.25
- MetaSVM -0.83
- CADD 0.82
- PolyPhen-2 0.21
- SIFT 0.29
- ClinVar: drug response (Voriconazole response; Citalopram response; Sertraline response)
- EBI: Drug response
- UniProt: Drug response
- Most common in the Middle Eastern population (allele frequency 0.0011)
- Structural context available
- CYP2C19 VAMP-seq nonsynonymous scores: score 1.02