P35T (p.Pro35Thr) variant of CYP2C19 (Cytochrome P450 2C19)
P35T (p.Pro35Thr) in CYP2C19 (Cytochrome P450 2C19) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.16 / 1. The record also includes population frequency data, experimental measurements, and structural context.
P35T (p.Pro35Thr) variant details
- p.Pro35Thr
- TOPMed rs1408512455
- gnomAD rs1408512455
- Missense
- Variant Prioritization Score for Impact Estimate 0.157
- REVEL 0.08
- MetaLR 0.09
- MetaSVM -0.99
- CADD 21.00
- PolyPhen-2 0.96
- SIFT 0.01
- Most common in the Non-Finnish European population (allele frequency 5.8e-05)
- Structural context available
- CYP2C19 VAMP-seq nonsynonymous scores: score 0.295