P35S (p.Pro35Ser) variant of CYP2C19 (Cytochrome P450 2C19)
P35S (p.Pro35Ser) in CYP2C19 (Cytochrome P450 2C19) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.15 / 1. The record also includes population frequency data, experimental measurements, and structural context.
P35S (p.Pro35Ser) variant details
- p.Pro35Ser
- TOPMed rs1408512455
- gnomAD rs1408512455
- Missense
- Variant Prioritization Score for Impact Estimate 0.151
- REVEL 0.07
- MetaLR 0.06
- MetaSVM -1.08
- CADD 21.00
- PolyPhen-2 0.70
- SIFT 0.03
- Most common in the African/African-American population (allele frequency 2.8e-05)
- Structural context available
- CYP2C19 VAMP-seq nonsynonymous scores: score 0.295