P33A (p.Pro33Ala) variant of CYP2C19 (Cytochrome P450 2C19)
P33A (p.Pro33Ala) in CYP2C19 (Cytochrome P450 2C19) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.36 / 1. The record also includes population frequency data, experimental measurements, published literature, and structural context.
P33A (p.Pro33Ala) variant details
- p.Pro33Ala
- gnomAD 10-94762802-C-G
- Missense
- Variant Prioritization Score for Impact Estimate 0.365
- REVEL 0.24
- MetaLR 0.22
- MetaSVM -0.53
- CADD 21.00
- PolyPhen-2 0.99
- SIFT 0.00
- Population evidence available
- Structural context available
- CYP2C19 VAMP-seq nonsynonymous scores: score 0.111
- Literature evidence available