M1V (p.Met1Val) variant of CYP2C19 (Cytochrome P450 2C19)
M1V (p.Met1Val) in CYP2C19 (Cytochrome P450 2C19) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as drug response in the context of Voriconazole response; Clopidogrel response; Citalopram response. The record also includes population frequency data, experimental measurements, published literature, and structural context.
M1V (p.Met1Val) variant details
- p.Met1Val
- rs28399504
- ClinGen CA250055
- ClinVar RCV000018399
- ClinVar RCV000383294
- drug response
- Voriconazole response; Clopidogrel response; Citalopram response
- Missense
- ClinVar: drug response (Voriconazole response; Clopidogrel response; Citalopram response)
- EBI: Likely benign
- UniProt: Likely benign
- Population evidence available
- Structural context available
- CYP2C19 VAMP-seq nonsynonymous scores: score 0.188
- Cited in: A new genetic defect in human CYP2C19: mutation of the initiation codon is responsible for poor metabolism of… (PMID 9435198)