L9P (p.Leu9Pro) variant of CYP2C19 (Cytochrome P450 2C19)
L9P (p.Leu9Pro) in CYP2C19 (Cytochrome P450 2C19) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.36 / 1. The record also includes population frequency data, experimental measurements, and structural context.
L9P (p.Leu9Pro) variant details
- p.Leu9Pro
- TOPMed rs1223517617
- gnomAD rs1223517617
- Missense
- Variant Prioritization Score for Impact Estimate 0.364
- REVEL 0.23
- MetaLR 0.54
- MetaSVM -0.59
- CADD 22.50
- PolyPhen-2 0.98
- SIFT 0.03
- Most common in the REMAINING population (allele frequency 1.7e-05)
- Structural context available
- CYP2C19 VAMP-seq nonsynonymous scores: score 0.919