L9F (p.Leu9Phe) variant of CYP2C19 (Cytochrome P450 2C19)
L9F (p.Leu9Phe) in CYP2C19 (Cytochrome P450 2C19) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.24 / 1. The record also includes population frequency data, experimental measurements, published literature, and structural context.
L9F (p.Leu9Phe) variant details
- p.Leu9Phe
- gnomAD 10-94762730-C-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.242
- REVEL 0.07
- MetaLR 0.25
- MetaSVM -0.83
- CADD 7.49
- PolyPhen-2 0.30
- SIFT 0.22
- Most common in the Non-Finnish European population (allele frequency 9.3e-07)
- Structural context available
- CYP2C19 VAMP-seq nonsynonymous scores: score 0.919
- Literature evidence available