L7P (p.Leu7Pro) variant of CYP2C19 (Cytochrome P450 2C19)
L7P (p.Leu7Pro) in CYP2C19 (Cytochrome P450 2C19) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.33 / 1. The record also includes population frequency data, experimental measurements, and structural context.
L7P (p.Leu7Pro) variant details
- p.Leu7Pro
- ExAC rs754219797
- gnomAD rs754219797
- Missense
- Variant Prioritization Score for Impact Estimate 0.333
- REVEL 0.18
- MetaLR 0.50
- MetaSVM -0.47
- CADD 22.50
- PolyPhen-2 0.98
- SIFT 0.00
- Most common in the Finnish in Finland (FIN) population (allele frequency 3.8e-05)
- Structural context available
- CYP2C19 VAMP-seq nonsynonymous scores: score 0.0352