L7F (p.Leu7Phe) variant of CYP2C19 (Cytochrome P450 2C19)
L7F (p.Leu7Phe) in CYP2C19 (Cytochrome P450 2C19) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.13 / 1. The record also includes population frequency data, experimental measurements, and structural context.
L7F (p.Leu7Phe) variant details
- p.Leu7Phe
- ExAC rs764485894
- gnomAD rs764485894
- Missense
- Variant Prioritization Score for Impact Estimate 0.13
- REVEL 0.08
- MetaLR 0.24
- MetaSVM -0.76
- CADD 7.66
- PolyPhen-2 0.31
- SIFT 0.05
- Most common in the Ashkenazi Jewish population (allele frequency 5.1e-05)
- Structural context available
- CYP2C19 VAMP-seq nonsynonymous scores: score 0.0352