L29F (p.Leu29Phe) variant of CYP2C19 (Cytochrome P450 2C19)
L29F (p.Leu29Phe) in CYP2C19 (Cytochrome P450 2C19) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.10 / 1. The record also includes population frequency data, experimental measurements, and structural context.
L29F (p.Leu29Phe) variant details
- p.Leu29Phe
- ExAC rs765463278
- TOPMed rs765463278
- gnomAD rs765463278
- Missense
- Variant Prioritization Score for Impact Estimate 0.0986
- REVEL 0.04
- MetaLR 0.04
- MetaSVM -1.06
- CADD 9.71
- PolyPhen-2 0.35
- SIFT 0.06
- Most common in the REMAINING population (allele frequency 1.7e-05)
- Structural context available
- CYP2C19 VAMP-seq nonsynonymous scores: score 0.954