L16L (p.Leu16Leu) variant of CYP2C19 (Cytochrome P450 2C19)
L16L (p.Leu16Leu) in CYP2C19 (Cytochrome P450 2C19) is a synonymous change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.12 / 1. The record also includes population frequency data, experimental measurements, published literature, and structural context.
L16L (p.Leu16Leu) variant details
- p.Leu16Leu
- rs267602631
- gnomAD 10-94762753-C-T
- Synonymous
- Variant Prioritization Score for Impact Estimate 0.125
- CADD 6.25
- Most common in the Ashkenazi Jewish population (allele frequency 5.1e-05)
- Structural context available
- CYP2C19 VAMP-seq nonsynonymous scores: score 0.947
- Literature evidence available