K59E (p.Lys59Glu) variant of CYP2C19 (Cytochrome P450 2C19)
K59E (p.Lys59Glu) in CYP2C19 (Cytochrome P450 2C19) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.24 / 1. The record also includes population frequency data, experimental measurements, and structural context.
K59E (p.Lys59Glu) variant details
- p.Lys59Glu
- gnomAD rs1301653527
- Missense
- Variant Prioritization Score for Impact Estimate 0.242
- REVEL 0.14
- MetaLR 0.16
- MetaSVM -0.92
- CADD 7.56
- PolyPhen-2 0.04
- SIFT 0.55
- Most common in the Non-Finnish European population (allele frequency 9.9e-07)
- Structural context available
- CYP2C19 VAMP-seq nonsynonymous scores: score 0.714