I60T (p.Ile60Thr) variant of CYP2C19 (Cytochrome P450 2C19)
I60T (p.Ile60Thr) in CYP2C19 (Cytochrome P450 2C19) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.20 / 1. The record also includes population frequency data, experimental measurements, and structural context.
I60T (p.Ile60Thr) variant details
- p.Ile60Thr
- TOPMed rs1848387737
- Missense
- Variant Prioritization Score for Impact Estimate 0.204
- REVEL 0.12
- MetaLR 0.05
- MetaSVM -1.05
- CADD 0.41
- PolyPhen-2 0.00
- SIFT 0.57
- Most common in the Non-Finnish European population (allele frequency 5.8e-05)
- Structural context available
- CYP2C19 VAMP-seq nonsynonymous scores: score 0.761