I45V (p.Ile45Val) variant of CYP2C19 (Cytochrome P450 2C19)
I45V (p.Ile45Val) in CYP2C19 (Cytochrome P450 2C19) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.16 / 1. The record also includes population frequency data, experimental measurements, and structural context.
I45V (p.Ile45Val) variant details
- p.Ile45Val
- gnomAD rs1205649887
- Missense
- Variant Prioritization Score for Impact Estimate 0.159
- REVEL 0.04
- MetaLR 0.01
- MetaSVM -1.05
- CADD 0.02
- PolyPhen-2 0.02
- SIFT 0.35
- Most common in the Non-Finnish European population (allele frequency 9.3e-07)
- Structural context available
- CYP2C19 VAMP-seq nonsynonymous scores: score 0.774