I19V (p.Ile19Val) variant of CYP2C19 (Cytochrome P450 2C19)
I19V (p.Ile19Val) in CYP2C19 (Cytochrome P450 2C19) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.08 / 1. The record also includes population frequency data, experimental measurements, published literature, and structural context.
I19V (p.Ile19Val) variant details
- p.Ile19Val
- gnomAD 10-94762760-A-G
- Missense
- Variant Prioritization Score for Impact Estimate 0.0847
- REVEL 0.06
- MetaLR 0.10
- MetaSVM -1.02
- CADD 0.77
- PolyPhen-2 0.00
- SIFT 0.42
- Most common in the African/African-American population (allele frequency 2.8e-05)
- Structural context available
- CYP2C19 VAMP-seq nonsynonymous scores: score 0.0906
- Literature evidence available