G62A (p.Gly62Ala) variant of CYP2C19 (Cytochrome P450 2C19)
G62A (p.Gly62Ala) in CYP2C19 (Cytochrome P450 2C19) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.47 / 1. The record also includes population frequency data, experimental measurements, and structural context.
G62A (p.Gly62Ala) variant details
- p.Gly62Ala
- ExAC rs770401619
- TOPMed rs770401619
- gnomAD rs770401619
- Missense
- Variant Prioritization Score for Impact Estimate 0.474
- REVEL 0.44
- MetaLR 0.24
- MetaSVM -0.31
- CADD 25.20
- PolyPhen-2 0.61
- SIFT 0.17
- Most common in the Non-Finnish European population (allele frequency 9.9e-07)
- Structural context available
- CYP2C19 VAMP-seq nonsynonymous scores: score 0.086