G32D (p.Gly32Asp) variant of CYP2C19 (Cytochrome P450 2C19)
G32D (p.Gly32Asp) in CYP2C19 (Cytochrome P450 2C19) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.43 / 1. The record also includes population frequency data, experimental measurements, and structural context.
G32D (p.Gly32Asp) variant details
- p.Gly32Asp
- cosmic curated COSV10821
- Ensembl rs1564656987
- Missense
- Variant Prioritization Score for Impact Estimate 0.428
- REVEL 0.36
- MetaLR 0.21
- MetaSVM -0.21
- CADD 23.10
- PolyPhen-2 1.00
- SIFT 0.01
- Most common in the Non-Finnish European population (allele frequency 9.9e-07)
- Structural context available
- CYP2C19 VAMP-seq nonsynonymous scores: score 0.247