G27R (p.Gly27Arg) variant of CYP2C19 (Cytochrome P450 2C19)
G27R (p.Gly27Arg) in CYP2C19 (Cytochrome P450 2C19) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.23 / 1. The record also includes population frequency data, experimental measurements, and structural context.
G27R (p.Gly27Arg) variant details
- p.Gly27Arg
- NCI-TCGA Cosmic COSV6490
- cosmic curated COSV64908
- gnomAD rs1848189454
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.23
- REVEL 0.07
- MetaLR 0.13
- MetaSVM -1.05
- CADD 7.88
- SIFT 0.34
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 1.8e-06)
- Structural context available
- CYP2C19 VAMP-seq nonsynonymous scores: score 0.924