G27E (p.Gly27Glu) variant of CYP2C19 (Cytochrome P450 2C19)
G27E (p.Gly27Glu) in CYP2C19 (Cytochrome P450 2C19) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.30 / 1. The record also includes population frequency data, experimental measurements, and structural context.
G27E (p.Gly27Glu) variant details
- p.Gly27Glu
- cosmic curated COSV10529
- Ensembl rs868067933
- Missense
- Variant Prioritization Score for Impact Estimate 0.302
- REVEL 0.14
- MetaLR 0.27
- MetaSVM -0.80
- CADD 15.90
- PolyPhen-2 0.49
- SIFT 0.13
- Most common in the Non-Finnish European population (allele frequency 1.8e-06)
- Structural context available
- CYP2C19 VAMP-seq nonsynonymous scores: score 0.924