F4S (p.Phe4Ser) variant of CYP2C19 (Cytochrome P450 2C19)
F4S (p.Phe4Ser) in CYP2C19 (Cytochrome P450 2C19) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.18 / 1. The record also includes population frequency data, experimental measurements, and structural context.
F4S (p.Phe4Ser) variant details
- p.Phe4Ser
- TOPMed rs1480091346
- gnomAD rs1480091346
- Missense
- Variant Prioritization Score for Impact Estimate 0.181
- REVEL 0.05
- MetaLR 0.14
- MetaSVM -1.00
- CADD 1.79
- PolyPhen-2 0.01
- SIFT 0.29
- Most common in the Non-Finnish European population (allele frequency 1.5e-05)
- Structural context available
- CYP2C19 VAMP-seq nonsynonymous scores: score 1.01