D2Y (p.Asp2Tyr) variant of CYP2C19 (Cytochrome P450 2C19)
D2Y (p.Asp2Tyr) in CYP2C19 (Cytochrome P450 2C19) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.32 / 1. The record also includes population frequency data, experimental measurements, published literature, and structural context.
D2Y (p.Asp2Tyr) variant details
- p.Asp2Tyr
- gnomAD 10-94762709-G-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.318
- REVEL 0.33
- MetaLR 0.49
- MetaSVM -0.80
- CADD 23.80
- PolyPhen-2 0.99
- SIFT 0.03
- Population evidence available
- Structural context available
- CYP2C19 VAMP-seq nonsynonymous scores: score 0.987
- Literature evidence available