R57W (p.Arg57Trp) variant of CYP2B6 (Cytochrome P450 2B6)
R57W (p.Arg57Trp) in CYP2B6 (Cytochrome P450 2B6) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.20 / 1. The record also includes population frequency data and structural context.
R57W (p.Arg57Trp) variant details
- p.Arg57Trp
- ExAC rs766255380
- gnomAD rs766255380
- Missense
- Variant Prioritization Score for Impact Estimate 0.196
- REVEL 0.12
- MetaLR 0.28
- MetaSVM -0.74
- CADD 22.80
- PolyPhen-2 0.90
- SIFT 0.02
- Most common in the Middle Eastern population (allele frequency 0.00073)
- Structural context available