R35S (p.Arg35Ser) variant of CYP2B6 (Cytochrome P450 2B6)
R35S (p.Arg35Ser) in CYP2B6 (Cytochrome P450 2B6) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.11 / 1. The record also includes population frequency data and structural context.
R35S (p.Arg35Ser) variant details
- p.Arg35Ser
- rs755215477
- NCI-TCGA Cosmic COSV6069
- cosmic curated COSV60698
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.109
- REVEL 0.03
- MetaLR 0.01
- MetaSVM -0.90
- CADD 0.63
- PolyPhen-2 0.01
- SIFT 0.45
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available