R35L (p.Arg35Leu) variant of CYP2B6 (Cytochrome P450 2B6)
R35L (p.Arg35Leu) in CYP2B6 (Cytochrome P450 2B6) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.14 / 1. The record also includes population frequency data and structural context.
R35L (p.Arg35Leu) variant details
- p.Arg35Leu
- ExAC rs781365650
- TOPMed rs781365650
- gnomAD rs781365650
- Missense
- Variant Prioritization Score for Impact Estimate 0.136
- REVEL 0.04
- MetaLR 0.01
- MetaSVM -0.92
- CADD 0.46
- SIFT 0.67
- Most common in the African/African-American population (allele frequency 2.4e-05)
- Structural context available