R35H (p.Arg35His) variant of CYP2B6 (Cytochrome P450 2B6)
R35H (p.Arg35His) in CYP2B6 (Cytochrome P450 2B6) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.16 / 1. The record also includes population frequency data and structural context.
R35H (p.Arg35His) variant details
- p.Arg35His
- rs781365650
- NCI-TCGA Cosmic COSV6069
- cosmic curated COSV60699
- ExAC rs781365650
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.159
- REVEL 0.08
- MetaLR 0.01
- MetaSVM -0.93
- CADD 1.07
- PolyPhen-2 0.37
- SIFT 0.59
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the South Asian population (allele frequency 8.1e-05)
- Structural context available