R35C (p.Arg35Cys) variant of CYP2B6 (Cytochrome P450 2B6)
R35C (p.Arg35Cys) in CYP2B6 (Cytochrome P450 2B6) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.14 / 1. The record also includes population frequency data and structural context.
R35C (p.Arg35Cys) variant details
- p.Arg35Cys
- ExAC rs755215477
- TOPMed rs755215477
- gnomAD rs755215477
- Missense
- Variant Prioritization Score for Impact Estimate 0.138
- REVEL 0.05
- MetaLR 0.01
- MetaSVM -0.90
- CADD 8.62
- PolyPhen-2 0.01
- SIFT 0.20
- Most common in the South Asian population (allele frequency 4.6e-05)
- Structural context available