R22P (p.Arg22Pro) variant of CYP2B6 (Cytochrome P450 2B6)
R22P (p.Arg22Pro) in CYP2B6 (Cytochrome P450 2B6) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.27 / 1. The record also includes population frequency data and structural context.
R22P (p.Arg22Pro) variant details
- p.Arg22Pro
- ESP rs375553471
- ExAC rs375553471
- TOPMed rs375553471
- gnomAD rs375553471
- Missense
- Variant Prioritization Score for Impact Estimate 0.271
- REVEL 0.21
- MetaLR 0.17
- MetaSVM -0.87
- CADD 18.40
- PolyPhen-2 0.08
- SIFT 0.13
- Most common in the Middle Eastern population (allele frequency 0.0029)
- Structural context available