R22H (p.Arg22His) variant of CYP2B6 (Cytochrome P450 2B6)
R22H (p.Arg22His) in CYP2B6 (Cytochrome P450 2B6) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.24 / 1. The record also includes population frequency data and structural context.
R22H (p.Arg22His) variant details
- p.Arg22His
- cosmic curated COSV10013
- ESP rs375553471
- ExAC rs375553471
- TOPMed rs375553471
- Missense
- Variant Prioritization Score for Impact Estimate 0.238
- REVEL 0.15
- MetaLR 0.15
- MetaSVM -0.86
- CADD 17.70
- PolyPhen-2 0.12
- SIFT 0.16
- Most common in the REMAINING population (allele frequency 3.3e-05)
- Structural context available