P34L (p.Pro34Leu) variant of CYP2B6 (Cytochrome P450 2B6)
P34L (p.Pro34Leu) in CYP2B6 (Cytochrome P450 2B6) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.35 / 1. The record also includes population frequency data and structural context.
P34L (p.Pro34Leu) variant details
- p.Pro34Leu
- NCI-TCGA Cosmic COSV1001
- cosmic curated COSV10013
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.355
- REVEL 0.14
- MetaLR 0.04
- MetaSVM -1.09
- CADD 21.70
- PolyPhen-2 1.00
- SIFT 0.01
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available