P31L (p.Pro31Leu) variant of CYP2B6 (Cytochrome P450 2B6)
P31L (p.Pro31Leu) in CYP2B6 (Cytochrome P450 2B6) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.55 / 1. The record also includes population frequency data and structural context.
P31L (p.Pro31Leu) variant details
- p.Pro31Leu
- cosmic curated COSV10518
- Missense
- Variant Prioritization Score for Impact Estimate 0.554
- REVEL 0.50
- MetaLR 0.69
- MetaSVM 0.47
- CADD 21.50
- PolyPhen-2 0.97
- SIFT 0.01
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available