M46T (p.Met46Thr) variant of CYP2B6 (Cytochrome P450 2B6)
M46T (p.Met46Thr) in CYP2B6 (Cytochrome P450 2B6) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.34 / 1. The record also includes population frequency data and structural context.
M46T (p.Met46Thr) variant details
- p.Met46Thr
- TOPMed rs1171619187
- gnomAD rs1171619187
- Missense
- Variant Prioritization Score for Impact Estimate 0.338
- REVEL 0.19
- MetaLR 0.01
- MetaSVM -1.09
- CADD 22.60
- PolyPhen-2 0.81
- SIFT 0.56
- Most common in the African/African-American population (allele frequency 2.4e-05)
- Structural context available